One thing I learned early on was defensive flying. I've never jet can mined. I've never AFK mined. If I can't take the time to warp to zero on a gate, I simply dock up until I have the time. I use fast warp outs on all the major and minor trade hubs as well as any other station I frequent. I have never auto piloted with cargo in the hold - ever. And the only reason for all of this is simple paranoia. It's my hard work; I'll do whatever is necessary to see it to market.
This philosophy has served me well in Anoikis. Out here, there really is a cloaked strategic cruiser behind every Customs Office. Anyone not blue is out to get you - and sometimes even the blues. There is no such thing as a safe route. Paranoia is your best strategy as a carebear.
To that end, I've put together an eight minute video on how to fly paranoid while doing your Planetary Interaction pickups and cross leveling. Since POCOs are fixed in space and easily camped, they are a natural ambush location. This video covers the technique I use to minimize risk and the reasons I use it. This technique is easily practiced in high-sec and you should practice: it works well everywhere. Make it a habit. It will save your cargo one day.
PS: I really thought about blanking certain things out of this video for operational security reasons. But it took my friend Kao Jai, whom I did not tell where home is, less than 60 seconds to figure it out. He went to the SYJ killboard and then he went to http://wormhole.es and started entering J numbers. If he could do it, anyone can do it - no offense Kao. It's just that easy to figure out so there is no sense in hiding it.